Sequence of this protein is as follows: MCPGNWLWAS MTFMARFSRS SSRSPVRTRG TLEEMPTVQH PFLNVFELER LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR GTPEAYEGLG IRYLGVEAHD SPAFDMSIHF QTAADFIHRA LSQPGGKILV HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK KVKDHRGIIP NRGFLRQLLA LDRRLRQGLE A
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
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Protein Aliases: DSP-4; Dual specificity phosphatase SKRP3; Dual specificity protein phosphatase 26; Low-molecular-mass dual-specificity phosphatase 4; MAP kinase phosphatase 8; MGC1136; MGC2627; Mitogen-activated protein kinase phosphatase 8; neuroendocrine-associated phosphatase; Novel amplified gene in thyroid anaplastic cancer
Gene Aliases: DSP-4; DUSP24; DUSP26; LDP-4; LDP4; MKP-8; MKP8; NATA1; NEAP; SKRP3
UniProt ID: (Human) Q9BV47
Entrez Gene ID: (Human) 78986