Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DSP-4; Dual specificity phosphatase SKRP3; Dual specificity protein phosphatase 26; dual-specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; MAP kinase phosphatase 8; MGC1136; MGC2627; Mitogen-activated protein kinase phosphatase 8; neuroendocrine-associated phosphatase; Novel amplified gene in thyroid anaplastic cancer
Gene Aliases: 2310043K02Rik; DSP-4; DUSP24; DUSP26; LDP-4; LDP4; MKP-8; MKP8; NATA1; NEAP; RGD1310090; SKRP3