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Invitrogen
DUSP26 Polyclonal Antibody
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Product Details
PA5-32740
Product Specifications
Species Reactivity
Bat,
Horse,
Hamster,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from internal region of human DUSP26.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Mouse, Bat, Hamster, Elephant, Panda, Horse (100%); Marmoset, Rat, Rabbit, Opossum, Platypus (94%); Bovine, Pig (89%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DSP-4; dual specificity phosphatase 26 (putative); Dual specificity phosphatase SKRP3; Dual specificity protein phosphatase 26; dual specificity protein phosphatase 26-like protein; dual-specificity phosphatase SKRP3; dual-specificity protein phosphatase: MKP8; Low-molecular-mass dual-specificity phosphatase 4; MAP kinase phosphatase 8; MGC1136; MGC2627; Mitogen-activated protein kinase phosphatase 8; NATA1; neuroendocrine-associated phosphatase; Novel amplified gene in thyroid anaplastic cancer; unnamed protein product
Gene Aliases: 2310043K02Rik; DSP-4; DUSP24; DUSP26; LDP-4; LDP4; MKP-8; MKP8; NATA1; NEAP; SKRP3
UniProt ID: (Human) Q9BV47, (Mouse) Q9D700
Entrez Gene ID: (Human) 78986, (Horse) 100058104, (Mouse) 66959, (Chinese hamster) 100761425
p53 binding
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/serine/threonine phosphatase activity
hydrolase activity
phosphatase activity
MAP kinase phosphatase activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
RNA polymerase II activating transcription factor binding
phosphoserine phosphatase activity
negative regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
dephosphorylation
peptidyl-tyrosine dephosphorylation
negative regulation of protein kinase activity by regulation of protein phosphorylation
positive regulation of cell adhesion
negative regulation of ERK1 and ERK2 cascade
positive regulation of peptidyl-serine dephosphorylation
negative regulation of MAPK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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