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Invitrogen
DUSP5 Polyclonal Antibody
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FIGURE: 1 / 2
DUSP5 Antibody (PA5-44870) in WB
Western blot analysis of DUSP5 was performed by loading 35 µg of MiaPaCa-2 lysate in reducing sample buffer and Page Rµler Protein Ladder (Product # 26616) onto a 10% polyacrylamide gel. Proteins were transferred to PVDF membrane using the wet transfer method. Membrane was blocked in 5% milk. DUSP5 was detected at approximately 37 kDa using a DUSP5 polyclonal antibody (Product # PA5-44870) at a dilution of 1:500 in 5% milk, followed by a goat anti-rabbit IgG DyLight 800 conjugated secondary antibody (Product # SA5-35571) at a dilution of 1... View More
Product Details
PA5-44870
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human DUSP5
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA5-44870 detects DUSP5 in WB application.
Peptide sequence: AGSSLIGHLQ TLSPDMQGAY CTFPASVLAP VPTHSTVSEL SRSPVATATS
Sequence homology: Cow: 85%; Dog: 92%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 86%; Rat: 79%
Target Information
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein kinase superfamily, which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 5; Dual specificity protein phosphatase hVH3; serine/threonine specific protein phosphatase; VH1-like phosphatase 3
Gene Aliases: DUSP; DUSP5; HVH3; VH3
UniProt ID: (Human) Q16690
Entrez Gene ID: (Human) 1847
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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