Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X and MKP-4.
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Protein Aliases: Dual specificity protein phosphatase 9; dual-specificity MAP kinase phosphatase 4; MAP kinase phosphatase 4; Mitogen-activated protein kinase phosphatase 4; serine/threonine specific protein phosphatase
Gene Aliases: Dusp4; DUSP9; MKP-4; MKP4; Mpk4; Pyst3
UniProt ID: (Human) Q99956