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Proteintech
DVL1 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-27384
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DVL1 fusion protein Ag26055
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LGQGYPYQY PGPPPCFPPA YQDPGFSYGS GSTGSQQSEG SKSSGSTRSS RRAPGREKER RAAGAGGSGS ESDHTAPSGV GSSWRERPAG QLSRGSSPRS QASATAPGLP PPHPTTKAYT VVGGPPGGPP VRELA
Target Information
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1
Gene Aliases: DRS2; DVL; DVL1; DVL1L1; DVL1P1; mKIAA4029
UniProt ID: (Human) O14640, (Mouse) P51141
Entrez Gene ID: (Human) 1855, (Mouse) 13542
regulation of neurotransmitter levels
positive regulation of protein phosphorylation
transcription from RNA polymerase II promoter
negative regulation of protein kinase activity
neurotransmitter secretion
axon guidance
synapse assembly
heart development
neuromuscular junction development
positive regulation of neuron projection development
neural tube development
convergent extension involved in neural plate elongation
positive regulation of Wnt signaling pathway
cytoplasmic microtubule organization
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein localization to nucleus
social behavior
protein localization to microtubule
intracellular signal transduction
receptor clustering
positive regulation of transcription, DNA-templated
collateral sprouting
axon extension
dendrite morphogenesis
synapse organization
protein stabilization
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
prepulse inhibition
skeletal muscle acetylcholine-gated channel clustering
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to synapse
regulation of cellular protein localization
beta-catenin destruction complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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