Peptide sequence: LKITIANAVI GADVVDWLYT HVEGFKERRE ARKYASSLLK HGFLRHTVNK
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 87%
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.
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Protein Aliases: Dishevelled; dishevelled 1; dishevelled 1 (homologous to Drosophila dsh); dishevelled segment polarity protein 1; dishevelled, dsh homolog 1; Dishevelled-1; DSH homolog 1; dsh homolog 1 (Drosophila); DVL; DVL1L1; MGC54245; Segment polarity protein dishevelled homolog DVL-1
Gene Aliases: BOS_16058; DRS2; DVL; dvl-1; DVL1; DVL1L1; DVL1P1; mKIAA4029