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Invitrogen
DVL2 Polyclonal Antibody
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FIGURE: 1 / 2
DVL2 Antibody (720060) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized MCF-7 cells for detection of Dishevelled using Anti-Dishevelled DVL-2 Rabbit Polyclonal Antibody (Product # 720060, 1 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Dishevelled protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S3693... View More
Product Details
720060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptides corresponding to Human DVL2 (aa 232-249, 596-613)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 30% glycerol, 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Rat, Mouse, Pig, Rabbit and Bovine.
Target Information
Disheveled DVL2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dishevelled 2; dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; Segment polarity protein dishevelled homolog DVL-2; unnamed protein product
Gene Aliases: Dvl-2; DVL2
UniProt ID: (Human) O14641, (Mouse) Q60838
Entrez Gene ID: (Human) 1856, (Mouse) 13543, (Rat) 303251
neural tube closure
heart looping
heart morphogenesis
outflow tract morphogenesis
regulation of transcription, DNA-templated
segment specification
heart development
protein localization
Wnt signaling pathway
convergent extension involved in neural plate elongation
regulation of actin cytoskeleton organization
segmentation
intracellular signal transduction
non-canonical Wnt signaling pathway
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
convergent extension involved in organogenesis
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
cochlea morphogenesis
positive regulation of neuron projection arborization
positive regulation of signal transduction by p53 class mediator
positive regulation of protein phosphorylation
transcription from RNA polymerase II promoter
multicellular organism development
cellular protein localization
positive regulation of JUN kinase activity
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of protein tyrosine kinase activity
planar cell polarity pathway involved in neural tube closure
positive regulation of canonical Wnt signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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