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Proteintech

DVL2 Polyclonal Antibody, CoraLite® Plus 488

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Product Details

CL488-12037

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:200-1:800
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DVL2 fusion protein Ag2666

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MAGSSTGGG GVGETKVIYH LDEEETPYLV KIPVPAERIT LGDFKSVLQR PAGAKYFFKS MDQDFGVVKE EISDDNARLP CFNGRVVSWL VSSDNPQPEM APPVHEPRAE LAPPAPPLPP LPPERTSGIG DSRPPSFHPN VSSSHENLEP ETETESVVSL RRERPRRRDS SEHGAGGHRT GGPSRLERHL AGYESSSTLM TSELESTSLG DSDEEDTMSR FSSSTEQSSA SRLLKRHRRR RKQRPPRLER TSSFSSVTDS TMSLNIITVT LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ VNDMNFENMS NDDAVRVLRD I

Target Information

Disheveled DVL2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dishevelled 2; dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; Segment polarity protein dishevelled homolog DVL-2; unnamed protein product

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Gene Aliases: Dvl-2; DVL2

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UniProt ID: (Human) O14641, (Mouse) Q60838

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Entrez Gene ID: (Human) 1856, (Mouse) 13543, (Rat) 303251

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Function(s)
frizzled binding protein binding protein kinase binding protein domain specific binding protein binding, bridging small GTPase binding identical protein binding protein self-association scaffold/adaptor protein
Process(es)
neural tube closure heart looping heart morphogenesis outflow tract morphogenesis regulation of transcription, DNA-templated segment specification heart development protein localization Wnt signaling pathway convergent extension involved in neural plate elongation regulation of actin cytoskeleton organization segmentation intracellular signal transduction non-canonical Wnt signaling pathway regulation of cell proliferation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade convergent extension involved in organogenesis canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway cochlea morphogenesis positive regulation of neuron projection arborization positive regulation of signal transduction by p53 class mediator positive regulation of protein phosphorylation transcription from RNA polymerase II promoter multicellular organism development cellular protein localization positive regulation of JUN kinase activity canonical Wnt signaling pathway involved in regulation of cell proliferation positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein tyrosine kinase activity planar cell polarity pathway involved in neural tube closure positive regulation of canonical Wnt signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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