Peptide sequence: AGSSTGGGGV GETKVIYHLD EEETPYLVKI PVPAERITLG DFKSVLQRPA
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%; Zebrafish: 93%
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
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Protein Aliases: Dishevelled; dishevelled 2; dishevelled 2 (homologous to Drosophila dsh); dishevelled 2, dsh homolog; dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; dsh homolog 2 (Drosophila); Segment polarity protein dishevelled homolog DVL-2
Gene Aliases: BOS_18753; Dvl-2; DVL2; sb:eu471; wu:fc05d12; wu:fo71e09; wu:fp54a02; zgc:55372