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DYRK1A Polyclonal Antibody
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Product Details
BS-11834R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DYRK1A, amino acids 81-170.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DYRK1A is a dual specificity kinase involved in cell proliferation. The gene for DYRK1A is located in the Down syndrome critical region of chromosome 21, and has been implicated in the pathogenesis of this disease. DYRK1A catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual Specificity Yak1-related kinase; HP86; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MP86; OTTHUMP00000109090; Protein kinase minibrain homolog; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase; unnamed protein product
Gene Aliases: 2310043O08Rik; D16Ertd272e; D16Ertd493e; DYRK; DYRK1; DYRK1A; ENSMUSG00000074897; Gm10783; HP86; mmb; MNB; MNBH; Mp86; MRD7; PSK47
UniProt ID: (Human) Q13627, (Mouse) Q61214, (Rat) Q63470
Entrez Gene ID: (Human) 1859, (Mouse) 13548, (Rat) 25255
nucleotide binding
transcription coactivator activity
actin binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
cytoskeletal protein binding
RNA polymerase II carboxy-terminal domain kinase activity
tubulin binding
kinase activity
transferase activity
identical protein binding
tau protein binding
tau-protein kinase activity
protein serine kinase activity
histone H3T45 kinase activity
splicing factor binding
transferase activity, transferring phosphorus-containing groups
protein self-association
regulation of alternative mRNA splicing, via spliceosome
protein phosphorylation
circadian rhythm
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
negative regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
positive regulation of protein deacetylation
nervous system development
regulation of endocytosis
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
negative regulation of microtubule polymerization
negative regulation of heterochromatin assembly
positive regulation of RNA splicing
positive regulation of transcription, DNA-templated
regulation of beta-amyloid formation
regulation of neurofibrillary tangle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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