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Product Details
PA5-142885
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.5 µg/mL | - |
Immunoprecipitation (IP) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Goat / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Peptide with sequence PHSHQYSDRRQPN-C. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
TBS, pH 7.3, with 0.5% BSA |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Additional Information: This antibody is expected to recognize all reported isoforms (NP_001387.2; NP_569120.1; NP_567824.1; NP_569122.1). This antibody is not expected to cross-react with DYRK1B.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; hMNB; HP86; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; OTTHUMP00000109090; Protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Gene Aliases: DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH; MRD7
UniProt ID: (Human) Q13627
Entrez Gene ID: (Human) 1859
regulation of alternative mRNA splicing, via spliceosome
protein phosphorylation
nervous system development
circadian rhythm
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
negative regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
positive regulation of protein deacetylation
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
identical protein binding
protein self-association
tau protein binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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