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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with mouse, rat and Xenopus based on sequence homology.
DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity YAK1-related kinase; hMNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase
DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH; MRD7