FIGURE: 1 / 3
A suggested positive control is Hela cell lysate.
PA5-21124 can be used with blocking peptide PEP-1238.
DYRK1A is a dual specificity kinase involved in cell proliferation. The gene for DYRK1A is located in the Down syndrome critical region of chromosome 21, and has been implicated in the pathogenesis of this disease. DYRK1A catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
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Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual Specificity Yak1-related kinase; hMNB; HP86; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MP86; OTTHUMP00000109090; Protein kinase minibrain homolog; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Gene Aliases: 2310043O08Rik; D16Ertd272e; D16Ertd493e; DYRK; DYRK1; DYRK1A; ENSMUSG00000074897; Gm10783; HP86; mmb; MNB; MNBH; Mp86; MRD7; PSK47