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Invitrogen
DYRK2/DYRK4 Polyclonal Antibody
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Product Details
PA5-106245
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DYRK2(Accession Q92630), corresponding to amino acid residues G360-C410.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DYRK2/4.
Target Information
DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4; Dual specificity tyrosine-phosphorylation-regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 4; Dyrk2; protein kinase; unnamed protein product
Gene Aliases: DYRK2; DYRK4
UniProt ID: (Human) Q92630, (Human) Q9NR20
Entrez Gene ID: (Human) 8445, (Human) 8798
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
manganese ion binding
protein serine kinase activity
metal ion binding
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
smoothened signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of glycogen biosynthetic process
negative regulation of calcineurin-NFAT signaling cascade
regulation of signal transduction by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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