This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
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Protein Aliases: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; cytotoxic TRAIL receptor-3; DcR1; Death-promoting deoxyribonuclease; Decoy receptor 1; Decoy TRAIL receptor without death domain; Endoribonuclease dcr-1; helicase MOI; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928; Lymphocyte inhibitor of TRAIL; tDCR-1; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL receptor without an intracellular domain; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Gene Aliases: CD263; CELE_K12H4.8; dcr-1; DCR1; DCR1-TNFR; K12H4.8; LIT; TNFRSF10C; TRAIL-R3; TRAILR3; TRID; UNQ321/PRO366
UniProt ID: (Human) O14798