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This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
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Protein Aliases: Endoribonuclease dcr-1; helicase MOI; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928
Gene Aliases: CELE_K12H4.8; dcr-1; eri-4; K12H4.8; let-740
UniProt ID: (C. elegans) P34529
Entrez Gene ID: (C. elegans) 176138
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