The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
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Protein Aliases: dcr-1; Death-promoting deoxyribonuclease; Endoribonuclease dcr-1; tDCR-1
Gene Aliases: CELE_K12H4.8; dcr-1; K12H4.8
UniProt ID: (C. elegans) P34529
Entrez Gene ID: (C. elegans) 176138