Immunogen sequence: TYPWRDAETG ERLVCAQCPP GTFVQRPCRR DSPTTCGPCP PRHYTQFWNY LERCRYCNVL CGEREEEARA CHATHNRACR CRTGFFAHAG FCLEHASCPP GAGVIAPGTP SQNTQCQPCP PGTFSASSSS SEQCQPHRNC TALGLALNVP GSSSHDTLCT SCTGFPLSTR VPGAEECERA VIDFVAFQDI SIKRLQRLLQ ALEAPEGWGP TPRAGRAALQ LKLRRRLTEL LGAQDGALLV RLLQALRVAR MPGLERSVRE RFLPVH; Positive Samples: HT-1080, Mouse lung
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
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Protein Aliases: DcR3; Decoy receptor 3; decoy receptor 3 variant 1; decoy receptor 3 variant 2; Decoy receptor for Fas ligand; hCG_2044836; M68; OTTHUMP00000031583; Tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily member 6b, decoy; tumor necrosis factor receptor superfamily, member 6b, decoy
Gene Aliases: DCR3; DJ583P15.1.1; M68; M68E; TNFRSF6B; TR6; UNQ186/PRO212
UniProt ID: (Human) O95407
Entrez Gene ID: (Human) 8771
Molecular Function: transmembrane signal receptor