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Decorin Polyclonal Antibody

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Decorin Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( -20°C Ethanol ) fixed BxPC-3 cells using 14667-1-AP (Decorin antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Decorin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human ovary using 14667-1-AP (Decorin antibody) at dilution of 1:50 (under 10x lens).

Decorin Antibody in Western Blot (WB) — mouse heart tissue were subjected to SDS PAGE followed by western blot with 14667-1-AP (Decorin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

14667-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 7 publications 7 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:50-1:500	View 1 publication 1 publication
Immunohistochemistry (IHC)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Hamster, Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Decorin Fusion Protein Ag6328 (1-359 aa encoded by BC005322) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.18 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MKATIILLL LAQVSWAGPF QQRGLFDFML EDEASGIGPE VPDDRDFEPS LGPVCPFRCQ CHLRVVQCSD LGLDKVPKDL PPDTTLLDLQ NNKITEIKDG DFKNLKNLHA LILVNNKISK VSPGAFTPLV KLERLYLSKN QLKELPEKMP KTLQELRAHE NEITKVRKVT FNGLNQMIVI ELGTNPLKSS GIENGAFQGM KKLSYIRIAD TNITSIPQGL PPSLTELHLD GNKISRVDAA SLKGLNNLAK LGLSFNSISA VDNGSLANTP HLRELHLDNN KLTRVPGGLA EHKYIQVVYL HNNNISVVGS SDFCPPGHNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV RSAIQLGNYK (1-359 aa encoded by BC005322)

Target Information

Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Negative impact of hyperglycaemia on mouse alveolar development.

Cell cycle (Georgetown, Tex.)

He MY,Wang G,Han SS,Li K,Jin Y,Liu M,Si ZP,Wang J,Liu GS,Yang X

Thu Sep 05 00:00:00 EDT 2019

Negative impact of hyperglycaemia on mouse alveolar development.

Cell cycle (Georgetown, Tex.)

He MY,Wang G,Han SS,Li K,Jin Y,Liu M,Si ZP,Wang J,Liu GS,Yang X

Thu Sep 05 00:00:00 EDT 2019

Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity.

Journal of cellular physiology

Wang H,Ning T,Song C,Luo X,Xu S,Zhang X,Deng Z,Ma D,Wu B

Thu Aug 01 00:00:00 EDT 2019

Identification of CAV1 and DCN as potential predictive biomarkers for lung adenocarcinoma.

American journal of physiology. Lung cellular and molecular physiology

Yan Y,Xu Z,Qian L,Zeng S,Zhou Y,Chen X,Wei J,Gong Z

Mon Apr 01 00:00:00 EDT 2019

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice.

Pharmaceutical biology

Wang Y,Guan M,Zhao X,Li X

Sat Dec 01 00:00:00 EST 2018

Cellular response to persistent foot-and-mouth disease virus infection is linked to specific types of alterations in the host cell transcriptome.

Scientific reports

Han L,Xin X,Wang H,Li J,Hao Y,Wang M,Zheng C,Shen C

Thu Mar 22 00:00:00 EDT 2018

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

PLoS genetics

Chan WL,Steiner M,Witkos T,Egerer J,Busse B,Mizumoto S,Pestka JM,Zhang H,Hausser I,Khayal LA,Ott CE,Kolanczyk M,Willie B,Schinke T,Paganini C,Rossi A,Sugahara K,Amling M,Knaus P,Chan D,Lowe M,Mundlos S,Kornak U

Thu Mar 01 00:00:00 EST 2018

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

PLoS genetics

Thu Mar 01 00:00:00 EST 2018

Effects of polysaccharide from Physalis alkekengi var. francheti on liver injury and intestinal microflora in type-2 diabetic mice.

Pharmaceutical biology

Zhao X,Chen Z,Yin Y,Li X

Fri Dec 01 00:00:00 EST 2017

Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.

Journal of proteomics

Chen SX,Xu XE,Wang XQ,Cui SJ,Xu LL,Jiang YH,Zhang Y,Yan HB,Zhang Q,Qiao J,Yang PY,Liu F

Tue Oct 14 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Bone proteoglycan II; Decorin; Dermatan sulfate proteoglycan-II; dermatan sulfate proteoglycan-II (decorin); dermatan sulphate proteoglycans II; Dermatan sulphate proteoglycans II (DSPG2); DSPG; PG-S2; PG40; proteoglycan core protein; Small leucine rich protein 1B; small leucine-rich protein 1B

Gene Aliases: CSCD; DC; DCN; DSPG2; mDcn; PG40; PGII; PGS2; SLRR1B

UniProt ID: (Human) P07585, (Mouse) P28654, (Rat) Q01129

Entrez Gene ID: (Human) 1634, (Mouse) 13179, (Rat) 29139

Function(s)

positive regulation of autophagy peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan kidney development placenta development skeletal muscle tissue development aging response to mechanical stimulus response to lipopolysaccharide wound healing negative regulation of protein kinase activity organ morphogenesis negative regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of macroautophagy negative regulation of angiogenesis cytokine-mediated signaling pathway extracellular matrix disassembly extracellular matrix organization glycosaminoglycan metabolic process chondroitin sulfate biosynthetic process chondroitin sulfate catabolic process dermatan sulfate biosynthetic process positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade positive regulation of mitochondrial depolarization positive regulation of mitochondrial fission negative regulation of vascular endothelial growth factor signaling pathway

Process(es)

protein kinase inhibitor activity protein binding collagen binding glycosaminoglycan binding poly(A) RNA binding protein N-terminus binding extracellular matrix binding

Decorin Polyclonal Antibody

Product Details

14667-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunohistochemistry (IHC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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