Proteintech

Decorin Polyclonal Antibody

Decorin Antibody in Immunocytochemistry (ICC/IF)

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Decorin Antibody (14667-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed BxPC-3 cells using 14667-1-AP (Decorin antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Decorin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

14667-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Hamster, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Decorin Fusion Protein Ag6328 (1-359 aa encoded by BC005322)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKATIILLL LAQVSWAGPF QQRGLFDFML EDEASGIGPE VPDDRDFEPS LGPVCPFRCQ CHLRVVQCSD LGLDKVPKDL PPDTTLLDLQ NNKITEIKDG DFKNLKNLHA LILVNNKISK VSPGAFTPLV KLERLYLSKN QLKELPEKMP KTLQELRAHE NEITKVRKVT FNGLNQMIVI ELGTNPLKSS GIENGAFQGM KKLSYIRIAD TNITSIPQGL PPSLTELHLD GNKISRVDAA SLKGLNNLAK LGLSFNSISA VDNGSLANTP HLRELHLDNN KLTRVPGGLA EHKYIQVVYL HNNNISVVGS SDFCPPGHNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV RSAIQLGNYK (1-359 aa encoded by BC005322)

Target Information

Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Cancer cell

Chen Y,Zhu S,Liu T,Zhang S,Lu J,Fan W,Lin L,Xiang T,Yang J,Zhao X,Xi Y,Ma Y,Cheng G,Lin D,Wu C

Mon May 08 00:00:00 UTC 2023

Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1.

Acta biomaterialia

Lu J,Yang X,He C,Chen Y,Li C,Li S,Chen Y,Wu Y,Xiang Z,Kang J,Jiang G,Wang C,Diarra MD,He R,Feng G,Yan R

Sat Apr 15 00:00:00 UTC 2023

Temporal changes in the muscle extracellular matrix due to volumetric muscle loss injury.

Connective tissue research

Hoffman DB,Raymond-Pope CJ,Sorensen JR,Corona BT,Greising SM

Tue Mar 01 00:00:00 UTC 2022

Decorin Promotes Osteoblastic Differentiation of Human Periodontal Ligament Stem Cells.

Molecules (Basel, Switzerland)

Adachi O,Sugii H,Itoyama T,Fujino S,Kaneko H,Tomokiyo A,Hamano S,Hasegawa D,Obata J,Yoshida S,Kadowaki M,Sugiura R,Albougha MS,Maeda H

Fri Nov 25 00:00:00 UTC 2022

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts.

Frontiers in pharmacology

Blokland KEC,Nizamoglu M,Habibie H,Borghuis T,Schuliga M,Melgert BN,Knight DA,Brandsma CA,Pouwels SD,Burgess JK

Tue Nov 22 00:00:00 UTC 2022

An integrated map of fibroblastic populations in human colon mucosa and cancer tissues.

Communications biology

Li S,Lu R,Shu L,Chen Y,Zhao J,Dai J,Huang Q,Li X,Meng W,Long F,Li Y,Fan C,Zhou Z,Mo X

Sat Dec 03 00:00:00 UTC 2022

Single-cell RNA sequencing analysis to characterize cells and gene expression landscapes in atrial septal defect.

Journal of cellular and molecular medicine

Wang Z,Wang H,Zhang Y,Yu F,Yu L,Zhang C

Fri Oct 01 00:00:00 UTC 2021

Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model.

Stem cell research & therapy

Shi Z,Wang Q,Zhang Y,Jiang D

Fri Jun 26 00:00:00 UTC 2020

Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes.

PloS one

Wang M,Li Z,Zhang M,Wang H,Zhang Y,Feng Y,Liu Y,Chen J

Mon Jul 27 00:00:00 UTC 2020

Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity.

Journal of cellular physiology

Wang H,Ning T,Song C,Luo X,Xu S,Zhang X,Deng Z,Ma D,Wu B

Thu Aug 01 00:00:00 UTC 2019

Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity.

Journal of cellular physiology

Wang H,Ning T,Song C,Luo X,Xu S,Zhang X,Deng Z,Ma D,Wu B

Thu Aug 01 00:00:00 UTC 2019

Identification of CAV1 and DCN as potential predictive biomarkers for lung adenocarcinoma.

American journal of physiology. Lung cellular and molecular physiology

Yan Y,Xu Z,Qian L,Zeng S,Zhou Y,Chen X,Wei J,Gong Z

Mon Apr 01 00:00:00 UTC 2019

Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency.

Glycoconjugate journal

Wang M,Xue S,Fang Q,Zhang M,He Y,Zhang Y,Lammi MJ,Cao J,Chen J

Sun Dec 01 00:00:00 UTC 2019

Hypomorphic mutations of TRIP11 cause odontochondrodysplasia.

JCI insight

Wehrle A,Witkos TM,Unger S,Schneider J,Follit JA,Hermann J,Welting T,Fano V,Hietala M,Vatanavicharn N,Schoner K,Spranger J,Schmidts M,Zabel B,Pazour GJ,Bloch-Zupan A,Nishimura G,Superti-Furga A,Lowe M,Lausch E

Thu Feb 07 00:00:00 UTC 2019

Quantitative proteomics reveal the alterations in the spinal cord after myocardial ischemia‑reperfusion injury in rats.

International journal of molecular medicine

Li SY,Li ZX,He ZG,Wang Q,Li YJ,Yang Q,Wu DZ,Zeng HL,Xiang HB

Fri Nov 01 00:00:00 UTC 2019

Negative impact of hyperglycaemia on mouse alveolar development.

Cell cycle (Georgetown, Tex.)

He MY,Wang G,Han SS,Li K,Jin Y,Liu M,Si ZP,Wang J,Liu GS,Yang X

Thu Sep 05 00:00:00 UTC 2019

Negative impact of hyperglycaemia on mouse alveolar development.

Cell cycle (Georgetown, Tex.)

He MY,Wang G,Han SS,Li K,Jin Y,Liu M,Si ZP,Wang J,Liu GS,Yang X

Thu Sep 05 00:00:00 UTC 2019

Negative impact of hyperglycaemia on mouse alveolar development.

Cell cycle (Georgetown, Tex.)

He MY,Wang G,Han SS,Li K,Jin Y,Liu M,Si ZP,Wang J,Liu GS,Yang X

Thu Sep 05 00:00:00 UTC 2019

Negative impact of hyperglycaemia on mouse alveolar development.

Cell cycle (Georgetown, Tex.)

He MY,Wang G,Han SS,Li K,Jin Y,Liu M,Si ZP,Wang J,Liu GS,Yang X

Thu Sep 05 00:00:00 UTC 2019

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Pharmaceutical biology

Wang Y,Guan M,Zhao X,Li X

Sat Dec 01 00:00:00 UTC 2018

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice.

Pharmaceutical biology

Wang Y,Guan M,Zhao X,Li X

Sat Dec 01 00:00:00 UTC 2018

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

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Chan WL,Steiner M,Witkos T,Egerer J,Busse B,Mizumoto S,Pestka JM,Zhang H,Hausser I,Khayal LA,Ott CE,Kolanczyk M,Willie B,Schinke T,Paganini C,Rossi A,Sugahara K,Amling M,Knaus P,Chan D,Lowe M,Mundlos S,Kornak U

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Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

PLoS genetics

Thu Mar 01 00:00:00 UTC 2018

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

PLoS genetics

Thu Mar 01 00:00:00 UTC 2018

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

PLoS genetics

Thu Mar 01 00:00:00 UTC 2018

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Scientific reports

Han L,Xin X,Wang H,Li J,Hao Y,Wang M,Zheng C,Shen C

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Cellular response to persistent foot-and-mouth disease virus infection is linked to specific types of alterations in the host cell transcriptome.

Scientific reports

Han L,Xin X,Wang H,Li J,Hao Y,Wang M,Zheng C,Shen C

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Effects of polysaccharide from Physalis alkekengi var. francheti on liver injury and intestinal microflora in type-2 diabetic mice.

Pharmaceutical biology

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Tue Oct 14 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Bone proteoglycan II; Decorin; Dermatan sulfate proteoglycan-II; dermatan sulfate proteoglycan-II (decorin); dermatan sulphate proteoglycans II; Dermatan sulphate proteoglycans II (DSPG2); DSPG; PG-S2; PG40; proteoglycan core protein; Small leucine rich protein 1B; small leucine-rich protein 1B

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Gene Aliases: CSCD; DC; DCN; DSPG2; mDcn; PG40; PGII; PGS2; SLRR1B

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UniProt ID: (Human) P07585, (Mouse) P28654, (Rat) Q01129

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Entrez Gene ID: (Human) 1634, (Mouse) 13179, (Rat) 29139

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Function(s)

protein kinase inhibitor activity protein binding collagen binding glycosaminoglycan binding poly(A) RNA binding protein N-terminus binding extracellular matrix binding

Process(es)

positive regulation of autophagy peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan kidney development placenta development skeletal muscle tissue development aging response to mechanical stimulus response to lipopolysaccharide wound healing negative regulation of protein kinase activity organ morphogenesis negative regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of macroautophagy negative regulation of angiogenesis cytokine-mediated signaling pathway extracellular matrix disassembly extracellular matrix organization glycosaminoglycan metabolic process chondroitin sulfate biosynthetic process chondroitin sulfate catabolic process dermatan sulfate biosynthetic process positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade positive regulation of mitochondrial depolarization positive regulation of mitochondrial fission negative regulation of vascular endothelial growth factor signaling pathway

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Decorin Polyclonal Antibody

Decorin Antibody (14667-1-AP) in ICC/IF

Product Details

14667-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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