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Invitrogen
Dectin 1 Polyclonal Antibody
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Product Details
PA5-34382
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid synthetic peptide near the center of human CLEC7A
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat spleen tissue lysate.
PA5-34382 can be used with blocking peptide PEP-1425.
Target Information
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beta-glucan receptor; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin BGRA; C-type lectin BGRB; C-type lectin BGRC; C-type lectin BGRD; C-type lectin BGRE; C-type lectin BGRF; C-type lectin BGRG; C-type lectin BGRH; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; CD369; DC-associated C-type lectin 1; dectin-1; dectin-1 beta; dectin-1; C-type lectin receptor; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; unnamed protein product
Gene Aliases: beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; DECTIN1; RGD1565140; SCARE2; UNQ539/PRO1082
UniProt ID: (Human) Q9BXN2
Entrez Gene ID: (Human) 64581, (Mouse) 56644, (Rat) 502902
response to yeast
detection of yeast
pattern recognition receptor signaling pathway
response to molecule of fungal origin
leukocyte activation involved in immune response
immune system process
cell surface pattern recognition receptor signaling pathway
phagocytosis, recognition
phagocytosis, engulfment
inflammatory response
cell recognition
single organismal cell-cell adhesion
positive regulation of tumor necrosis factor production
innate immune response
positive regulation of phagocytosis
cellular response to molecule of fungal origin
cell activation
stimulatory C-type lectin receptor signaling pathway
positive regulation of cytokine production involved in immune response
positive regulation of dendritic cell cytokine production
positive regulation of cell proliferation
carbohydrate mediated signaling
positive regulation of gene expression
detection of fungus
positive regulation of cell migration
positive regulation of protein complex assembly
detection of molecule of fungal origin
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-2 production
positive regulation of interleukin-23 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of superoxide anion generation
T cell activation
defense response to protozoan
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
leukocyte activation
positive regulation of nitric oxide biosynthetic process
positive regulation of calcium-mediated signaling
positive regulation of lymphocyte activation
positive regulation of respiratory burst
antifungal innate immune response
regulation of calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of monocyte chemotactic protein-1 production
positive regulation of wound healing
apoptotic signaling pathway
positive regulation of cytokine production involved in inflammatory response
positive regulation of cell maturation
positive regulation of T-helper 17 type immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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