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Proteintech
Desmin Polyclonal Antibody
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Product Details
16520-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Desmin Fusion Protein Ag9742 (121-470 aa encoded by BC032116)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NYIEKVRFL EQQNAALAAE VNRLKGREPT RVAELYEEEL RELRRQVEVL TNQRARVDVE RDNLLDDLQR LKAKLQEEIQ LKEEAENNLA AFRADVDAAT LARIDLERRI ESLNEEIAFL KKVHEEEIRE LQAQLQEQQV QVEMDMSKPD LTAALRDIRA QYETIAAKNI SEAEEWYKSK VSDLTQAANK NNDALRQAKQ EMMEYRHQIQ SYTCEIDALK GTNDSLMRQM RELEDRFASE ASGYQDNIAR LEEEIRHLKD EMARHLREYQ DLLNVKMALD VEIATYRKLL EGEESRINLP IQTYSALNFR ETSPEQRGSE VHTKKTVMIK TIETRDGEVV SEATQQQHEV L (121-470 aa encoded by BC032116)
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cardiomyocyte intermediate filament protein; cardiomyopathy, dilated 1F (autosomal dominant); cardiomyopathy, dilated 1I; CMD1I; Desmin; epididymis secretory sperm binding protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament; intermediate filament protein; MFM1; muscle specific intermediate filament; SCPNK; unnamed protein product
Gene Aliases: CDCD3; CSM1; CSM2; DES; LGMD1D; LGMD1E; LGMD2R
UniProt ID: (Human) P17661, (Rat) P48675, (Mouse) P31001
Entrez Gene ID: (Human) 1674, (Rat) 64362, (Mouse) 13346
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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