This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
PA5-16705 targets Desmin in IHC (P), IP, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The PA5-16705 immunogen is a synthetic peptide mapping near the C-terminus of human desmin.
PA5-16705 has been successfully used in immunofluorescence and western blotting analysis of Desmin in primary human hepatic stellate cells.
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CMD1I; Desmin; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; MFM1; mutant desmin p.K241E; SCPNK
Gene Aliases: CSM1; CSM2; DES; LGMD2R