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Proteintech
Desmoplakin Polyclonal Antibody
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Product Details
25318-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Desmoplakin Fusion Protein Ag18065 (1-350 aa encoded by BC140802)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects both DP1 (280-330 kDa) and DP2 (240-260 kDa).
Immunogen sequence: MSCNGGSHP RINTLGRMIR AESGPDLRYE VTSGGGGTSR MYYSRRGVIT DQNSDGYCQT GTMSRHQNQN TIQELLQNCS DCLMRAELIV QPELKYGDGI QLTRSRELDE CFAQANDQME ILDSLIREMR QMGQPCDAYQ KRLLQLQEQM RALYKAISVP RVRRASSKGG GGYTCQSGSG WDEFTKHVTS ECLGWMRQQR AEMDMVAWGV DLASVEQHIN SHRGIHNSIG DYRWQLDKIK ADLREKSAIY QLEEEYENLL KASFERMDHL RQLQNIIQAT SREIMWINDC EEEELLYDWS DKNTNIAQKQ EAFSIRMSQL EVKEKELNKL KQESDQLVLN QHPASDKIEA Y (1-350 aa encoded by BC140802)
Target Information
Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; desmoplakin I/II; Desmoplakin II; Desmoplakin-I; desmosomal cytoskeletal connector molecule; DP
Gene Aliases: 2300002E22Rik; 5730453H04Rik; AA407887; AA407888; AW109828; DCWHKTA; DP; DSP; rul
UniProt ID: (Human) P15924, (Mouse) E9Q557
Entrez Gene ID: (Human) 1832, (Mouse) 109620
protein kinase C binding
structural molecule activity
structural constituent of cytoskeleton
protein binding
protein binding, bridging
poly(A) RNA binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
scaffold protein binding
intermediate filament binding protein
desmosome organization
ventricular compact myocardium morphogenesis
epidermis development
peptide cross-linking
keratinocyte differentiation
adherens junction organization
wound healing
intermediate filament organization
protein localization to adherens junction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
single organismal cell-cell adhesion
skin development
intermediate filament cytoskeleton organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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