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Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; Desmoplakin II; Desmoplakin-I; DP
Gene Aliases: DCWHKTA; DP; DSP
UniProt ID: (Human) P15924
Entrez Gene ID: (Human) 1832
Molecular Function: intermediate filament binding protein