Immunogen sequence: MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD QNSDGYCQTG TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ; Positive Samples: A-431, Mouse heart; Cellular Location: Cell junction, Cytoplasm, cytoskeleton, desmosome
Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; desmoplakin I/II; Desmoplakin II; Desmoplakin-I; desmosomal cytoskeletal connector molecule; DP; Oculoglycan; Opticin
Gene Aliases: 2300002E22Rik; 5730453H04Rik; AA407887; AA407888; AW109828; DCWHKTA; DP; DSP; OPT; OPTC; rul
UniProt ID: (Human) P15924, (Mouse) E9Q557, (Human) Q9UBM4, (Mouse) Q920A0
Entrez Gene ID: (Human) 1832, (Mouse) 109620, (Rat) 306871, (Human) 26254, (Mouse) 269120, (Rat) 304802
Molecular Function:
actin family cytoskeletal protein
cytoskeletal protein
non-motor actin binding protein
extracellular matrix protein
receptor
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