Positive Control: Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, 293T, A431, HeLa, HepG2, MCF-7, SW480
Predicted Reactivity: Zebrafish (93%), Xenopus laevis (92%), Pig (99%), Chicken (96%), Rhesus Monkey (100%), Bovine (99%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DCR; DCR-1; dicer 1 ribonuclease III; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; Dicer1, Dcr-1 homolog; double-strand-specific ribonuclease mDCR-1; Endoribonuclease Dicer; Helicase MOI; Helicase with RNase motif; helicase-moi
Gene Aliases: 1110006F08Rik; D12Ertd7e; DCR1; DICER; DICER1; Dicer1e; HERNA; K12H4.8-LIKE; KIAA0928; mKIAA0928; MNG1; RMSE2
UniProt ID: (Human) Q9UPY3