This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-beta superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.
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Protein Aliases: DII B; distal-less homeo box 1; homeobox Dlx1; Homeobox protein DLX-1
Gene Aliases: Dlx; Dlx-1; DLX1
Molecular Function: homeodomain transcription factor