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Invitrogen
Drosha Polyclonal Antibody
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Product Details
PA5-103162
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DROSHA(Accession Q9NRR4), corresponding to amino acid residues H899-M949.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total RNase III Drosha.
Target Information
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ethanol induced 2; MGC115770; nuclear RNase III Drosha; OTTHUMP00000220910; OTTHUMP00000220911; OTTHUMP00000220912; OTTHUMP00000220913; p241; Protein Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RNase III
Gene Aliases: 1110013A17Rik; AI874853; DROSHA; ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN
UniProt ID: (Human) Q9NRR4, (Mouse) Q5HZJ0
Entrez Gene ID: (Human) 29102, (Mouse) 14000
lipopolysaccharide binding
double-stranded RNA binding
ribonuclease III activity
protein binding
protein homodimerization activity
poly(A) RNA binding
metal ion binding
primary miRNA binding
RNA binding
nuclease activity
endonuclease activity
endoribonuclease activity
hydrolase activity
endoribonuclease
miRNA metabolic process
positive regulation of gene expression
rRNA catabolic process
production of siRNA involved in RNA interference
gene silencing by RNA
primary miRNA processing
pre-miRNA processing
ribosome biogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
RNA phosphodiester bond hydrolysis, endonucleolytic
regulation of miRNA metabolic process
RNA processing
regulation of gene expression
RNA phosphodiester bond hydrolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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