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Proteintech
Dysbindin Polyclonal Antibody
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Product Details
11132-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Dysbindin Fusion Protein Ag1613 (1-351 aa encoded by BC011912)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes all of isoforms of dysbindin.
Immunogen sequence: MLETLRERL LSVQQDFTSG LKTLSDKSRE AKVKSKPRTV PFLPKYSAGL ELLSRYEDTW AALHRRAKDC ASAGELVDSE VVMLSAHWEK KKTSLVELQE QLQQLPALIA DLESMTANLT HLEASFEEVE NNLLHLEDLC GQCELERCKH MQSQQLENYK KNKRKELETF KAELDAEHAQ KVLEMEHTQQ MKLKERQKFF EEAFQQDMEQ YLSTGYLQIA ERREPIGSMS SMEVNVDMLE QMDLMDISDQ EALDVFLNSG GEENTVLSPA LGPESSTCQN EITLQVPNPS ELRAKPPSSS STCTDSATRD ISEGGESPVV QSDEEEVQVD TALATSHTDR EATPDGGEDS DS (1-351 aa encoded by BC011912)
Target Information
Dtnbp1 may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations are associated with Hermansky-Pudlak syndrome type 7. This protein may also be associated with schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; BLOC-1 subunit 8; distrobrevin binding protein 1; DKFZp564K192; DTBP1; Dysbindin; Dysbindin-1; Dystrobrevin-binding protein 1; FLJ30031; Hermansky-Pudlak syndrome 7 protein; Hermansky-Pudlak syndrome 7 protein homolog; HPS7 protein; HPS7 protein homolog; Hps7-like protein; MGC20210; OTTHUMP00000221462; OTTHUMP00000221485; RP1-147M19.1; sandy; subunit of BLOC-1; unnamed protein product
Gene Aliases: 5430437B18Rik; AW048963; BLOC1S8; DBND; DTNBP1; dysbindin; HPS7; My031; SDY
UniProt ID: (Human) Q96EV8, (Mouse) Q91WZ8, (Rat) Q5M834
Entrez Gene ID: (Human) 84062, (Mouse) 94245, (Rat) 641528
kidney development
positive regulation of neurotransmitter secretion
positive regulation of receptor internalization
blood coagulation
memory
anterograde axonal transport
regulation of signal transduction
positive regulation of gene expression
regulation of dopamine secretion
actin cytoskeleton organization
neuron projection development
melanosome organization
anterograde synaptic vesicle transport
neuron projection morphogenesis
dendrite morphogenesis
retina development in camera-type eye
platelet dense granule organization
regulation of dopamine receptor signaling pathway
cilium morphogenesis
negative regulation of dendritic spine morphogenesis
positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
protein transmembrane transport
regulation of synaptic vesicle exocytosis
organelle organization
muscle organ development
actin cytoskeleton reorganization
response to stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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