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Product Details
11132-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Miscellaneous PubMed (Misc) |
- | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Dysbindin Fusion Protein Ag1613 (1-351 aa encoded by BC011912) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.28 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
This antibody recognizes all of isoforms of dysbindin.
Immunogen sequence: MLETLRERL LSVQQDFTSG LKTLSDKSRE AKVKSKPRTV PFLPKYSAGL ELLSRYEDTW AALHRRAKDC ASAGELVDSE VVMLSAHWEK KKTSLVELQE QLQQLPALIA DLESMTANLT HLEASFEEVE NNLLHLEDLC GQCELERCKH MQSQQLENYK KNKRKELETF KAELDAEHAQ KVLEMEHTQQ MKLKERQKFF EEAFQQDMEQ YLSTGYLQIA ERREPIGSMS SMEVNVDMLE QMDLMDISDQ EALDVFLNSG GEENTVLSPA LGPESSTCQN EITLQVPNPS ELRAKPPSSS STCTDSATRD ISEGGESPVV QSDEEEVQVD TALATSHTDR EATPDGGEDS DS (1-351 aa encoded by BC011912)
Target Information
Dtnbp1 may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations are associated with Hermansky-Pudlak syndrome type 7. This protein may also be associated with schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; BLOC-1 subunit 8; distrobrevin binding protein 1; DKFZp564K192; DTBP1; Dysbindin; Dysbindin-1; Dystrobrevin-binding protein 1; FLJ30031; Hermansky-Pudlak syndrome 7 protein; Hermansky-Pudlak syndrome 7 protein homolog; HPS7 protein; HPS7 protein homolog; Hps7-like protein; MGC20210; OTTHUMP00000221462; OTTHUMP00000221485; RP1-147M19.1; sandy
Gene Aliases: 5430437B18Rik; AW048963; BLOC1S8; DBND; DTNBP1; dysbindin; HPS7; My031; SDY
UniProt ID: (Human) Q96EV8, (Mouse) Q91WZ8, (Rat) Q5M834
Entrez Gene ID: (Human) 84062, (Mouse) 94245, (Rat) 641528
positive regulation of neurotransmitter secretion
blood coagulation
anterograde axonal transport
positive regulation of gene expression
regulation of dopamine secretion
neuron projection development
actin cytoskeleton reorganization
melanosome organization
regulation of JUN kinase activity
anterograde synaptic vesicle transport
neuron projection morphogenesis
platelet dense granule organization
regulation of dopamine receptor signaling pathway
organelle organization
muscle organ development
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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