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Proteintech
Dystroglycan Polyclonal Antibody
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Product Details
11017-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Dystroglycan Fusion Protein Ag1456 (546-895 aa encoded by BC012740)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VGEKSWVQF NSNSQLMYGL PDSSHVGKHE YFMHATDKGG LSAVDAFEIH VHRRPQGDRA PARFKAKFVG DPALVLNDIH KKIALVKKLA FAFGDRNCST ITLQNITRGS IVVEWTNNTL PLEPCPKEQI AGLSRRIAED DGKPRPAFSN ALEPDFKATS ITVTGSGSCR HLQFIPVVPP RRVPSEAPPT EVPDRDPEKS SEDDVYLHTV IPAVVVAAIL LIAGIIAMIC YRKKRKGKLT LEDQATFIKK GVPIIFADEL DDSKPPPSSS MPLILQEEKA PLPPPEYPNQ SVPETTPLNQ DTMGEYTPLR DEDPNAPPYQ PPPPFTAPME GKGSRPKNMT PYRSPPPYVP P (546-895 aa encoded by BC012740)
Target Information
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-dystroglycan; beta-dystroglycan; Dystroglycan; Dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; unnamed protein product
Gene Aliases: 156DAG; A3a; AGRNR; D9Wsu13e; DAG; DAG1; DG; Dp427; Dp71; LGMDR16; MDDGA9; MDDGC7; MDDGC9
UniProt ID: (Human) Q14118, (Mouse) Q62165
Entrez Gene ID: (Human) 1605, (Mouse) 13138, (Rat) 114489
virus receptor activity
dystroglycan binding
actin binding
serine-type endopeptidase activity
calcium ion binding
protein binding
structural constituent of muscle
tubulin binding
vinculin binding
SH2 domain binding
laminin binding
laminin-1 binding
macromolecular complex binding
alpha-actinin binding
protein complex binding
cell adhesion molecule
positive regulation of cell-matrix adhesion
morphogenesis of an epithelium
morphogenesis of an epithelial sheet
heart morphogenesis
membrane protein ectodomain proteolysis
axon guidance
heart development
Schwann cell differentiation
Schwann cell development
response to muscle activity
response to denervation involved in regulation of muscle adaptation
protein transport
muscle attachment
calcium-dependent cell-matrix adhesion
nerve development
nerve maturation
myelination in peripheral nervous system
extracellular matrix organization
negative regulation of cell migration
axon regeneration
positive regulation of myelination
microtubule anchoring
skeletal muscle tissue regeneration
negative regulation of MAPK cascade
response to peptide hormone
viral entry into host cell
regulation of synaptic plasticity
positive regulation of oligodendrocyte differentiation
regulation of synapse organization
negative regulation of protein kinase B signaling
angiogenesis involved in wound healing
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
cellular response to mechanical stimulus
cellular response to cholesterol
commissural neuron axon guidance
basement membrane organization
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
retrograde trans-synaptic signaling by trans-synaptic protein complex
NLS-bearing protein import into nucleus
cytoskeletal anchoring at plasma membrane
viral process
modulation by virus of host morphology or physiology
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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