Fabgennix

E2F4 Polyclonal Antibody

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E2F4 Antibody in Western Blot (WB) — WB of E2F4-401AP with PC-E2F4. 1:500 antibody dilution in DiluObuffer. Apparent MW is 56 kDa.

Product Details

E2F4-401AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-
ELISA (ELISA)	1:10,000	-
Immunoprecipitation (IP)	1:50-1:250	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide taken within amino acid region 360-410 on mouse E2F4 protein. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5-1.5 mg/mL
Purification	Affinity chromatography
Storage buffer	proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Target Information

E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F-4 is regulated by complex formation with Rb p110. E2F family members bind DNA as heterodimers with members of the DP family of polypeptides Differential phosphorylation contributes to the microheterogeniety of E2F-4 (total aa 411-416, varies due to a trinucleotide repeat).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E2F transcription factor 4, p107/p130-binding; E2F-4; p107/p130-binding protein; Transcription factor E2F4

Gene Aliases: 2010111M04Rik; AI427446; E2F-4; E2F4

UniProt ID: (Human) Q16254, (Mouse) Q8R0K9

Entrez Gene ID: (Human) 1874, (Rat) 100360427, (Mouse) 104394

Molecular Function: RNA metabolism protein nucleic acid metabolism protein general transcription factor

regulation of transcription involved in G1/S transition of mitotic cell cycle epithelial cell development transcription from RNA polymerase II promoter cell volume homeostasis DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest blood circulation organ morphogenesis regulation of cell proliferation motile cilium assembly positive regulation of transcription from RNA polymerase II promoter centriole assembly multi-ciliated epithelial cell differentiation transcription, DNA-templated regulation of cell size cilium assembly mitotic cell cycle regulation of transcription, DNA-templated cell cycle cell projection organization regulation of cell cycle

Process(es)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein domain specific binding promoter-specific chromatin binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding