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Proteintech
EAAT3 Polyclonal Antibody
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Product Details
12686-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EAAT3 Fusion Protein Ag3379 (430-524 aa encoded by BC033040)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AEDVTLIIA VDWLLDRFRT MVNVLGDAFG TGIVEKLSKK ELEQMDVSSE VNIVNPFALE STILDNEDSD TKKSYVNGGF AVDKSDTISF TQTSQF (430-524 aa encoded by BC033040)
Target Information
L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: excitatory amino acid carrier 1; excitatory amino acid carrier 2; Excitatory amino acid transporter 3; excitatory amino acid transporter-3; Excitatory amino-acid carrier 1; glutamate transporter mEAAC2; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 A1 (brain glutamate transporter); Solute carrier family 1 member 1; solute carrier family 1, member 1
Gene Aliases: D130048G10Rik; DCBXA; EAAC1; EAAC2; EAAT3; HEAAC1; MEAAC1; REAAC1; SCZD18; SLC1A1
UniProt ID: (Human) P43005, (Mouse) P51906, (Rat) P51907
Entrez Gene ID: (Human) 6505, (Mouse) 20510, (Rat) 25550
L-glutamate transmembrane transporter activity
high-affinity glutamate transmembrane transporter activity
protein binding
amino acid transmembrane transporter activity
glutamate:sodium symporter activity
glutamate binding
cysteine transmembrane transporter activity
symporter activity
sodium:dicarboxylate symporter activity
primary active transporter
ion transport
chemical synaptic transmission
positive regulation of heart rate
glutamate secretion
cysteine transport
protein homooligomerization
L-glutamate import
D-aspartate import
L-glutamate transmembrane transport
cysteine transmembrane transport
transport
dicarboxylic acid transport
L-glutamate transport
sodium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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