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Product Details
11172-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
EAF2 Fusion Protein Ag1637 (1-260 aa encoded by BC014209) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.4 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
11172-1-AP is a rabbit polyclonal antibody raised against the full-length human EAF2 protein.
Immunogen sequence: MNSAAGFSH LDRRERVLKL GESFEKQPRC AFHTVRYDFK PASIDTSSEG YLEVGEGEQV TITLPNIEGS TPPVTVFKGS KKPYLKECIL IINHDTGECR LEKLSSNITV KKTRVEGSSK IQYRKEQQQQ QMWNSARTPN LVKHSPSEDK MSPASPIDDI ERELKAEASL MDQMSSCDSS SDSKSSSSSS SEDSSSDSED EDCKSSTSDT GNCVSGHPTM TQYRIPDIDA SHNRFRDNSG LLMNTLRNDL QLSESGSDSD D (1-260 aa encoded by BC014209)
Target Information
EAF1 and EAF2 can form a complex with ELL that targets the ternary elongation complex of Pol II, stimulating the rate of elongation. In addition, EAF1 and EAF2 are important for the stability of the NuA4 histone acetyltransferase complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. Both EAF1 and EAF2 are ubiquitously expressed members of the EAF family that colocalize with ELL to the the Cajal bodies and nuclear speckles. EAF1 contains a C-terminal region rich in aspartic acid, glutamic acid and serine residues. EAF2 is an androgen-response gene and can act as a potent apoptosis inducer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ehrlich S-II transcriptional activator factor; ELL-associated factor 2; testosterone regulated apoptosis inducer and tumor suppressor; Testosterone-regulated apoptosis inducer and tumor suppressor protein
Gene Aliases: AW048865; BM-040; BM040; EAF2; Festa; FESTA-L; FESTA-S; TRAITS; U19
UniProt ID: (Human) Q96CJ1, (Mouse) Q91ZD6, (Rat) Q811X5
Entrez Gene ID: (Human) 55840, (Mouse) 106389, (Rat) 266787
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of cell growth
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of epithelial cell proliferation involved in prostate gland development
intrinsic apoptotic signaling pathway
apoptotic process
biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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