This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: GFSHLDRRER VLKLGESFEK QPRCAFHTVR YDFKPASIDT SSEGYLEVGE GEQVTITLPN IEGSTPPVTV FKGSKKPYLK ECILIINHDT GECRL
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 89%.
EAF1 and EAF2 can form a complex with ELL that targets the ternary elongation complex of Pol II, stimulating the rate of elongation. In addition, EAF1 and EAF2 are important for the stability of the NuA4 histone acetyltransferase complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. Both EAF1 and EAF2 are ubiquitously expressed members of the EAF family that colocalize with ELL to the the Cajal bodies and nuclear speckles. EAF1 contains a C-terminal region rich in aspartic acid, glutamic acid and serine residues. EAF2 is an androgen-response gene and can act as a potent apoptosis inducer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ELL-associated factor 2; Testosterone-regulated apoptosis inducer and tumor suppressor protein
Gene Aliases: BM-040; BM040; EAF2; TRAITS; U19
UniProt ID: (Human) Q96CJ1
Entrez Gene ID: (Human) 55840