Positive Control: NT2D1
Predicted Reactivity: Rhesus Monkey (94%), Bovine (80%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: ecdysoneless homolog; hSGT1; Human suppressor of GCR two; Protein ecdysoneless homolog; protein SGT1; suppressor of GCR2; suppressor of S. cerevisiae gcr2
Gene Aliases: ECD; GCR2; HSGT1; SGT1
UniProt ID: (Human) O95905
Entrez Gene ID: (Human) 11319