Search
Bioss
ECE1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
BS-1190R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ECE1, amino acids 665-770.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Endothelin-converting enzyme 1 (ECE1) is located on chromosome 1p36.12 and encodes a zinc metalloprotease involved in the maturation of endothelin peptides, which are critical for vascular tone regulation and blood pressure control. ECE1 processes precursor proteins into active endothelins, particularly endothelin-1, the most potent vasoconstrictor known. This enzyme is expressed in multiple tissues, including endothelial cells, smooth muscle cells, and the central nervous system, where it participates in diverse physiological processes such as vasoconstriction, cell proliferation, and hormone secretion. Beyond its cardiovascular functions, ECE1 is implicated in neural development and neural crest cell migration. Dysregulation of ECE1 activity or endothelin signaling is associated with several pathologies, including hypertension, heart failure, and cancer progression due to its role in controlling vascular dynamics. Research into ECE1 aims to explore its therapeutic potential in managing cardiovascular disorders and its broader implications in systemic pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ECE 1; ECE-1; Endothelin-converting enzyme 1; endothelin-converting enzyme-1a; endothelin-converting enzyme-1b; endothelin-converting enzyme-1d; unnamed protein product
Gene Aliases: AW322500; ECE; ECE-1; ECE-1a; ECE-1b; ECE-1d; ECE1
UniProt ID: (Human) P42892, (Mouse) Q4PZA2
Entrez Gene ID: (Human) 1889, (Rat) 94204, (Mouse) 230857
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by endothelin
proteolysis
signal transduction
G-protein coupled receptor signaling pathway
axon guidance
heart development
anatomical structure morphogenesis
gene expression
substance P catabolic process
bradykinin catabolic process
calcitonin catabolic process
protein processing
peptide hormone processing
regulation of vasoconstriction
neuron projection development
endothelin maturation
embryonic heart tube development
hormone catabolic process
embryonic digit morphogenesis
ear development
pharyngeal system development
axonogenesis involved in innervation
sympathetic neuron axon guidance
semaphorin-plexin signaling pathway involved in axon guidance
response to hypoxia
apoptotic process
regulation of blood pressure
positive regulation of cardiac muscle hypertrophy
positive regulation of cAMP biosynthetic process
response to muscle stretch
regulation of vasodilation
response to drug
positive regulation of G-protein coupled receptor protein signaling pathway
response to cadmium ion
regulation of ERK1 and ERK2 cascade
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support