Invitrogen

ECE1 Polyclonal Antibody

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ECE1 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of ECE1 in human pancreas using a ECE1 polyclonal antibody (Product # PA5-81948). The analysis shows strong cytoplasmic positivity in exocrine glandular cells.

ECE1 Antibody in Western Blot (WB) — Western blot analysis of ECE1 by a ECE1 polyclonal antibody (Product # PA5-81948). Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human cell line U-87 MG.

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

Western Blot (WB)

0.04-0.4 µg/mL

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ECE1

Conjugate

Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2789109

Product Specific Information

Immunogen sequence: IMDPKELDKV FNDYTAVPDL YFENAMRFFN FSWRVTADQL RKAPNRDQWS MTPPMVNAYY SPTKNEIVFP AGILQAPFYT RSSPKALNFG GIGVVVGHEL THAFDDQGRE YDKDGNLRPW WKNSSVEAFK R

Target Information

ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ECE 1; ECE-1; Endothelin-converting enzyme 1

Gene Aliases: ECE; ECE1

UniProt ID: (Human) P42892

Entrez Gene ID: (Human) 1889

Molecular Function: hydrolase metalloprotease protease

Function(s)

response to hypoxia positive regulation of receptor recycling regulation of systemic arterial blood pressure by endothelin apoptotic process heart development positive regulation of cardiac muscle hypertrophy substance P catabolic process bradykinin catabolic process calcitonin catabolic process protein processing peptide hormone processing regulation of vasoconstriction positive regulation of cAMP biosynthetic process endothelin maturation response to muscle stretch regulation of vasodilation hormone catabolic process response to drug embryonic digit morphogenesis ear development positive regulation of G-protein coupled receptor protein signaling pathway response to cadmium ion pharyngeal system development regulation of ERK1 and ERK2 cascade

Process(es)

endopeptidase activity metalloendopeptidase activity protein binding peptide hormone binding protein homodimerization activity metal ion binding

ECE1 Polyclonal Antibody

Product Details

Product Specific Information

Target Information

References (0)

Bioinformatics

Material safety data sheets (MSDS)

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