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Invitrogen
ECT2 Polyclonal Antibody
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Product Details
PA5-43811
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human ECT2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: PECGRQSLVE LLIRPVQRLP SVALLLNDLK KHTADENPDK STLEKAIGSL
Sequence homology: Cow: 86%; Dog: 86%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Target Information
The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Epithelial cell-transforming sequence 2 oncogene; FLJ10461; guanine nucleotide exchange factor for Rho GTPases; MGC138291; Protein ECT2; Rho guanyl-nucleotide exchange factor; ECT2B; unnamed protein product
Gene Aliases: ARHGEF31; ECT2
UniProt ID: (Human) Q9H8V3
Entrez Gene ID: (Human) 1894
mitotic cytokinesis
cell morphogenesis
nervous system development
protein transport
cell differentiation
activation of protein kinase activity
positive regulation of cytokinesis
intracellular signal transduction
positive regulation of protein import into nucleus
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of GTPase activity
positive regulation of neuron differentiation
regulation of protein kinase activity
regulation of small GTPase mediated signal transduction
protein homooligomerization
cell division
regulation of attachment of spindle microtubules to kinetochore
cellular response to hydrogen peroxide
bicellular tight junction assembly
cellular response to calcium ion
cellular response to ionizing radiation
activation of GTPase activity
positive regulation of mitotic cytokinetic process
regulation of cytokinesis, actomyosin contractile ring assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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