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EDA2R Polyclonal Antibody
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Product Details
BS-7111R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human EDA2R/TNFRSF27, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappa-B and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ectodysplasin A2 isoform receptor; ectodysplasin A2 receptor; EDA-A2 receptor; receptor for ectodysplasin-A2; Tumor necrosis factor receptor superfamily member 27; tumor necrosis factor receptor superfamily member XEDAR; unnamed protein product; X linked ectodysplasin receptor; X-linked ectodysplasin-A2 receptor; X-linked EDA receptor
Gene Aliases: 9430060M22Rik; EDA-A2R; EDA2R; EDAA2R; RGD1564025; TNFRSF27; UNQ2448/PRO5727/PRO34080; XEDAR
UniProt ID: (Human) Q9HAV5, (Mouse) Q8BX35
Entrez Gene ID: (Human) 60401, (Rat) 296872, (Mouse) 245527
positive regulation of JNK cascade
positive regulation of NF-kappaB transcription factor activity
intrinsic apoptotic signaling pathway by p53 class mediator
epidermis development
ectodermal cell differentiation
cytokine-mediated signaling pathway
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
multicellular organism development
programmed cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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