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Product Details
PA5-120535
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 399-578 of human EDEM2 (NP_060687.2).
Conjugate
Form
Liquid
Concentration
1.96 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914107
Product Specific Information
Positive test controls include: A375, HepG2.
Immunogen sequence: SIEKISKVEC GFATIKDLRD HKLDNRMESF FLAETVKYLY LLFDPTNFIH NNGSTFDAVI TPYGECILGA GGYIFNTEAH PIDPAALHCC QRLKEEQWEV EDLMREFYSL KRSRSKFQKN TVSSGPWEPP ARPGTLFSPE NHDQARERKP AKQKVPLLSC PSQPFTSKLA LLGQVFLDSS
Target Information
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ER degradation enhancer, mannosidase alpha-like 2; ER degradation-enhancing alpha-mannosidase-like 2; ER degradation-enhancing alpha-mannosidase-like protein 2; ER degradation-enhancing-mannosidase-like protein 2
Gene Aliases: 9530090G24Rik; AI327354; bA4204.1; C20orf31; C20orf49; EDEM2; UNQ573/PRO1135
UniProt ID: (Human) Q9BV94, (Mouse) Q8BJT9
Entrez Gene ID: (Human) 55741, (Mouse) 108687
glycoprotein binding
alpha-mannosidase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
calcium ion binding
molecular_function
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
N-glycan processing
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
trimming of terminal mannose on B branch
glycoprotein ERAD pathway
positive regulation of retrograde protein transport, ER to cytosol
endoplasmic reticulum mannose trimming
mannose trimming involved in glycoprotein ERAD pathway
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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