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Invitrogen
EDG3 Polyclonal Antibody
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Product Details
PA1-33153
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from C-terminus of human EDG3 / S1P3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-33153 detects EDG3 from human samples.
Target Information
EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor Edg-3; S1P receptor EDG3; S1P receptor S1P3; sphingosine; Sphingosine 1-phosphate receptor 3; Sphingosine 1-phosphate receptor Edg-3
Gene Aliases: AI132464; C9orf108; C9orf47; EDG-3; EDG3; LPB3; S1P3; S1PR3
UniProt ID: (Human) Q99500, (Mouse) Q9Z0U9
Entrez Gene ID: (Human) 1903, (Mouse) 13610
cytokine production
sphingosine-1-phosphate signaling pathway
inflammatory response
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Notch signaling pathway
positive regulation of cell proliferation
anatomical structure morphogenesis
regulation of interleukin-1 beta production
negative regulation of establishment of endothelial barrier
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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