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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 314 and 378 of Human EDG3|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA5-28762 targets EDG3 in WB applications and shows reactivity with Human samples.
The PA5-28762 immunogen is synthetic peptide corresponding to a region within amino acids 314 and 378 of Human EDG3.
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
PA5-28762 was used in western blot to study the role of the sphingosine-1-phosphate in the mechanism by which acid ceramidase promotes oncogenic Akt signaling
|Beckham TH,Cheng JC,Lu P,Shao Y,Troyer D,Lance R,Marrison ST,Norris JS,Liu X||Oncogenesis (2:null)||2013|
3; EDG-3; EDG3; endothelial differentiation; endothelial differentiation G-protein coupled receptor 3; endothelial differentiation gene-3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; G protein-coupled receptor; G protein-coupled receptor, endothelial differentiation gene-3; LPB3; S1P receptor 3; S1P receptor Edg-3; S1P receptor EDG3; S1P3; sphingolipid G-protein-coupled receptor; sphingosine; sphingosine 1-phosphate receptor Edg-3
EDG-3; EDG3; LPB3; S1P3; S1PR3