Del-1 is an integrin ligand that is expressed by endothelial cells during embryological vascular development. It promotes adhesion of endothelial cells through an interaction with the alpha-v/beta-3 integrin receptor. Del-1 plays a vital role in mediating angiogenesis.
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Protein Aliases: developmental endothelial locus-1; Developmentally-regulated endothelial cell locus 1 protein; EGF-like repeat and discoidin I-like domain-containing protein 3; EGF-like repeats and discoidin I-like domains 3; Integrin-binding protein DEL1
Gene Aliases: Del-1; DEL1; EDIL3
Molecular Function: apolipoprotein cell adhesion molecule enzyme modulator extracellular matrix protein hydrolase membrane-bound signaling molecule metalloprotease oxidase oxidoreductase protease receptor serine protease signaling molecule transfer/carrier protein transporter