The EED protein (WAIT-1 or WD protein associated with integrin cytoplasmic tails-1), also called embryonic ectoderm development, is a member of the superfamily of WD-40 repeat proteins and widely conserved polycomb group (PcG) family of proteins. The polycomb group (PcG) is a large and evolutionarily conserved set of genes whose products act in multimeric complexes to modify histones, which are then thought to cause stable and heritable states of transcriptional repression. EED shuttles between the nucleus and the plasma membrane and can interact with the cytoplasmic tail of integrin Beta-7 subunit. EED exerted an antiviral activity at the late stage of HIV-1 replication.
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Protein Aliases: Embryonic ectoderm development protein; hEED; Polycomb protein EED; WAIT-1; WD protein associating with integrin cytoplasmic tails 1
Gene Aliases: EED; HEED; WAIT1
UniProt ID: (Human) O75530
Entrez Gene ID: (Human) 8726