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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 15 amino acid peptide near the center of human EFCAB4A.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is human lung tissue lysate.
PA5-21059 can be used with blocking peptide PEP-1173.
EFCAB4A, also known as Calcium release-activated calcium channel regulator 2B, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation, but the detailed function is still under investigation. It is likely to play a similar role as the related protein EFCAB4B, which acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ca2+ release-activated Ca2+ (CRAC) channel regulator 2B; calcium release-activated calcium channel regulator 2B; calcium release-activated channel regulator 2B; CRAC channel regulator 2B; CRAC regulator 2B; CRACR2B; EF-hand calcium binding domain 4A; EF-hand calcium-binding domain-containing protein 4A
6330520A15Rik; BC026645; Cracr2a; CRACR2B; Efcab4; EFCAB4A; RGD1560911