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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 14 amino acid peptide near the carboxy terminus of human EFCAB4B.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||10 µg/ml|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is mouse kidney tissue lysate.
PA5-21060 can be used with blocking peptide PEP-1174.
EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release-activated calcium channel regulator 2A; calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; CRACR2A; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B
CRACR2A; EFCAB4B; Gm1073; Gm462