Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
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Protein Aliases: Calcium uptake protein 2, mitochondrial; EF hand domain family A1; EF hand domain family, member A1; EF-hand domain family member A1; EF-hand domain family, member A1; EF-hand domain-containing family member A1; Smhs2 homolog
Gene Aliases: 1110008L20Rik; EFHA1; MICU2
UniProt ID: (Human) Q8IYU8
Entrez Gene ID: (Human) 221154