EGFL4 (epidermal growth factor-like protein 4), also known as MEGF8 (multiple epidermal growth factor-like domains protein 8) or C19orf49, is a 2,845 amino acid single-pass type I membrane protein. EGFL4 contains 2 CUB domains, 5 EGF-like domains, 12 Kelch repeats, 4 laminin EGF-like domains and 7 PSI domains. Existing as two alternatively spliced isoforms, the gene encoding EGFL4 maps to human chromosome 19q13.2. Chromosome 19 consists of approximately 63 million bases, makes up over 2% of human genomic DNA, and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors.
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Protein Aliases: EGF-like domain-containing protein 4; EGF-like protein 4; EGF-like-domain, multiple 4; Epidermal growth factor-like protein 4; HBV pre-s2 binding protein 1; HBV pre-S2-binding protein 1; hepatitis B virus pre-S2-binding protein 1; Multiple EGF-like domains protein 8; multiple EGF-like-domains 8; Multiple epidermal growth factor-like domains protein 8
Gene Aliases: C19orf49; CRPT2; EGFL4; KIAA0817; MEGF8; SBP1
UniProt ID: (Human) Q7Z7M0
Entrez Gene ID: (Human) 1954