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EGR2 Polyclonal Antibody

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EGR2 Antibody in Western Blot (WB) — Mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 13491-1-AP (EGR2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

13491-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 7 publications 7 publications
Immunohistochemistry (IHC)	Assay-dependent	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	EGR2 Fusion Protein Ag4313 (149-499 aa encoded by BC035625)
Conjugate	Unconjugated
Form	Liquid
Concentration	0.23 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against a region of human EGR2.

Immunogen sequence: LGVCTMSQT QPDLDHLYSP PPPPPPYSGC AGDLYQDPSA FLSAATTSTS SSLAYPPPPS YPSPKPATDP GLFPMIPDYP GFFPSQCQRD LHGTAGPDRK PFPCPLDTLR VPPPLTPLST IRKPFPCPLD TLRVPPPLTP LSTIRNFTLG GPSAGVTGPG ASGGSEGPRL PGSSSAAAAA AAAAAYNPHH LPLRPILRPR KYPNRPSKTP VHERPYPCPA EGCDRRFSRS DELTRHIRIH TGHKPFQCRI CMRNFSRSDH LTTHIRTHTG EKPFACDYCG RKFARSDERK RHTKIHLRQK ERKSSAPSAS VPAPSTASCS GGVQPGGTLC SSNSSSLGGG PLAPCSSRTR TP (149-499 aa encoded by BC035625)

Target Information

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells.

PloS one

Zeng T,Wang D,Chen J,Tian Y,Cai X,Peng H,Zhu L,Huang A,Tang H

Wed Oct 04 00:00:00 EDT 2017

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells.

PloS one

Zeng T,Wang D,Chen J,Tian Y,Cai X,Peng H,Zhu L,Huang A,Tang H

Wed Oct 04 00:00:00 EDT 2017

Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity.

Molecular neurobiology

Li Y,You QL,Zhang SR,Huang WY,Zou WJ,Jie W,Li SJ,Liu JH,Lv CY,Cong J,Hu YY,Gao TM,Li JM

Tue Apr 18 00:00:00 EDT 2017

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling.

International journal of molecular sciences

Takigawa S,Chen A,Nishimura A,Liu S,Li BY,Sudo A,Yokota H,Hamamura K

Thu May 05 00:00:00 EDT 2016

Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways.

Scientific reports

Liang YC,Yang MT,Lin CJ,Chang CL,Yang WC

Mon Apr 11 00:00:00 EDT 2016

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.

Nature communications

Gökbuget D,Pereira JA,Bachofner S,Marchais A,Ciaudo C,Stoffel M,Schulte JH,Suter U

Wed Oct 14 00:00:00 EDT 2015

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.

PloS one

Ogawa M,Okamura T,Ishikura S,Doi K,Matsuzaki H,Tanaka Y,Ota T,Hayakawa K,Suzuki H,Tsunoda T,Sasazuki T,Shirasawa S

Mon Jul 28 00:00:00 EDT 2014

Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells.

The international journal of biochemistry & cell biology

Wang SS,Huang HY,Chen SZ,Li X,Liu Y,Zhang WT,Tang QQ

Thu Aug 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: AT591; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; Early growth response protein 2; EGR-2; FLJ1454; FLJ14547; Krox-20 homolog; KROX-20, Drosophila, homolog (early growth response-2); OTTHUMP00000062133; Zinc finger protein Krox-20

Gene Aliases: AT591; CMT1D; CMT4E; Egr-2; EGR2; Krox-20; KROX20; NGF1-B; Zfp-25; Zfp-6

UniProt ID: (Human) P11161, (Mouse) P08152, (Rat) P51774

Entrez Gene ID: (Human) 1959, (Mouse) 13654, (Rat) 114090

Molecular Function: C2H2 zinc finger transcription factor