Proteintech

EGR2 Polyclonal Antibody

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EGR2 Antibody (13491-1-AP) in WB

Mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 13491-1-AP (EGR2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Product Details

13491-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

Assay-dependent

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EGR2 Fusion Protein Ag4313 (149-499 aa encoded by BC035625)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against a region of human EGR2.

Immunogen sequence: LGVCTMSQT QPDLDHLYSP PPPPPPYSGC AGDLYQDPSA FLSAATTSTS SSLAYPPPPS YPSPKPATDP GLFPMIPDYP GFFPSQCQRD LHGTAGPDRK PFPCPLDTLR VPPPLTPLST IRKPFPCPLD TLRVPPPLTP LSTIRNFTLG GPSAGVTGPG ASGGSEGPRL PGSSSAAAAA AAAAAYNPHH LPLRPILRPR KYPNRPSKTP VHERPYPCPA EGCDRRFSRS DELTRHIRIH TGHKPFQCRI CMRNFSRSDH LTTHIRTHTG EKPFACDYCG RKFARSDERK RHTKIHLRQK ERKSSAPSAS VPAPSTASCS GGVQPGGTLC SSNSSSLGGG PLAPCSSRTR TP (149-499 aa encoded by BC035625)

Target Information

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy.

Frontiers in pharmacology

Zhang ZJ,Wang KP,Huang YP,Jin C,Jiang H,Xiong L,Chen ZY,Wen Y,Liu ZT,Mo JG

Sat Jul 16 00:00:00 UTC 2022

Functional Characterization of Muscarinic Receptors in Human Schwann Cells.

International journal of molecular sciences

Piovesana R,Faroni A,Tata AM,Reid AJ

Fri Sep 11 00:00:00 UTC 2020

Development and Characterisation of an in vitro Model of Wallerian Degeneration.

Frontiers in bioengineering and biotechnology

Elsayed H,Faroni A,Ashraf MR,Osuji J,Wunderley L,Zhang L,Elsobky H,Mansour M,Zidan AS,Reid AJ

Mon Sep 28 00:00:00 UTC 2020

Sericin Nerve Guidance Conduit Delivering Therapeutically Repurposed Clobetasol for Functional and Structural Regeneration of Transected Peripheral Nerves.

ACS biomaterials science & engineering

Zhang L,Yang W,Xie H,Wang H,Wang J,Su Q,Li X,Song Y,Wang G,Wang L,Wang Z

Mon Mar 11 00:00:00 UTC 2019

M2 receptors activation modulates cell growth, migration and differentiation of rat Schwann-like adipose-derived stem cells.

Cell death discovery

Piovesana R,Faroni A,Magnaghi V,Reid AJ,Tata AM

Wed Sep 30 00:00:00 UTC 2020

MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease.

Journal of pediatric surgery

Wu F,Wen Z,Zhi Z,Li Y,Zhou L,Li H,Xu X,Tang W

Tue Oct 01 00:00:00 UTC 2019

LINC01939 inhibits the metastasis of gastric cancer by acting as a molecular sponge of miR-17-5p to regulate EGR2 expression.

Cell death & disease

Chen M,Fan L,Zhang SM,Li Y,Chen P,Peng X,Liu DB,Ma C,Zhang WJ,Zou ZW,Li PD

Fri Jan 25 00:00:00 UTC 2019

Characterization of neuromas in peripheral nerves and their effects on heterotopic bone formation.

Molecular pain

Minarelli J,Davis EL,Dickerson A,Moore WC,Mejia JA,Gugala Z,Olmsted-Davis EA,Davis AR

Mon Aug 12 00:00:00 UTC 2019

Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity.

Molecular neurobiology

Li Y,You QL,Zhang SR,Huang WY,Zou WJ,Jie W,Li SJ,Liu JH,Lv CY,Cong J,Hu YY,Gao TM,Li JM

Tue Apr 18 00:00:00 UTC 2017

Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity.

Molecular neurobiology

Li Y,You QL,Zhang SR,Huang WY,Zou WJ,Jie W,Li SJ,Liu JH,Lv CY,Cong J,Hu YY,Gao TM,Li JM

Tue Apr 18 00:00:00 UTC 2017

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells.

PloS one

Zeng T,Wang D,Chen J,Tian Y,Cai X,Peng H,Zhu L,Huang A,Tang H

Wed Oct 04 00:00:00 UTC 2017

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells.

PloS one

Zeng T,Wang D,Chen J,Tian Y,Cai X,Peng H,Zhu L,Huang A,Tang H

Wed Oct 04 00:00:00 UTC 2017

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells.

PloS one

Zeng T,Wang D,Chen J,Tian Y,Cai X,Peng H,Zhu L,Huang A,Tang H

Wed Oct 04 00:00:00 UTC 2017

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells.

PloS one

Zeng T,Wang D,Chen J,Tian Y,Cai X,Peng H,Zhu L,Huang A,Tang H

Wed Oct 04 00:00:00 UTC 2017

Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways.

Scientific reports

Liang YC,Yang MT,Lin CJ,Chang CL,Yang WC

Mon Apr 11 00:00:00 UTC 2016

Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways.

Scientific reports

Liang YC,Yang MT,Lin CJ,Chang CL,Yang WC

Mon Apr 11 00:00:00 UTC 2016

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling.

International journal of molecular sciences

Takigawa S,Chen A,Nishimura A,Liu S,Li BY,Sudo A,Yokota H,Hamamura K

Thu May 05 00:00:00 UTC 2016

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling.

International journal of molecular sciences

Takigawa S,Chen A,Nishimura A,Liu S,Li BY,Sudo A,Yokota H,Hamamura K

Thu May 05 00:00:00 UTC 2016

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.

Nature communications

Gökbuget D,Pereira JA,Bachofner S,Marchais A,Ciaudo C,Stoffel M,Schulte JH,Suter U

Wed Oct 14 00:00:00 UTC 2015

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.

Nature communications

Gökbuget D,Pereira JA,Bachofner S,Marchais A,Ciaudo C,Stoffel M,Schulte JH,Suter U

Wed Oct 14 00:00:00 UTC 2015

Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells.

The international journal of biochemistry & cell biology

Wang SS,Huang HY,Chen SZ,Li X,Liu Y,Zhang WT,Tang QQ

Thu Aug 01 00:00:00 UTC 2013

Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells.

The international journal of biochemistry & cell biology

Wang SS,Huang HY,Chen SZ,Li X,Liu Y,Zhang WT,Tang QQ

Thu Aug 01 00:00:00 UTC 2013

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.

PloS one

Ogawa M,Okamura T,Ishikura S,Doi K,Matsuzaki H,Tanaka Y,Ota T,Hayakawa K,Suzuki H,Tsunoda T,Sasazuki T,Shirasawa S

Mon Jul 28 00:00:00 UTC 2014

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.

PloS one

Ogawa M,Okamura T,Ishikura S,Doi K,Matsuzaki H,Tanaka Y,Ota T,Hayakawa K,Suzuki H,Tsunoda T,Sasazuki T,Shirasawa S

Mon Jul 28 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: AT591; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; Early growth response protein 2; EGR-2; FLJ1454; FLJ14547; Krox-20 homolog; KROX-20, Drosophila, homolog (early growth response-2); OTTHUMP00000062133; Zinc finger protein Krox-20

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Gene Aliases: AT591; CMT1D; CMT4E; Egr-2; EGR2; Krox-20; KROX20; NGF1-B; Zfp-25; Zfp-6

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UniProt ID: (Human) P11161, (Mouse) P08152, (Rat) P51774

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Entrez Gene ID: (Human) 1959, (Mouse) 13654, (Rat) 114090

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding ligase activity ubiquitin protein ligase binding transcription regulatory region DNA binding metal ion binding HMG box domain binding nucleic acid binding DNA binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity C2H2 zinc finger transcription factor

Process(es)

transcription from RNA polymerase II promoter protein export from nucleus brain development peripheral nervous system development learning or memory rhythmic behavior motor neuron axon guidance Schwann cell differentiation protein sumoylation facial nerve structural organization rhombomere 3 formation rhombomere 5 formation regulation of ossification response to insulin brain segmentation skeletal muscle cell differentiation myelination fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neuronal synaptic plasticity cellular response to organic substance transcription, DNA-templated regulation of transcription, DNA-templated rhombomere 3 development negative regulation of apoptotic process cellular response to cAMP cellular response to gonadotropin stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EGR2 Polyclonal Antibody

EGR2 Antibody (13491-1-AP) in WB

Product Details

13491-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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