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Proteintech
EHD1 Polyclonal Antibody
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Product Details
24657-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EHD1 Fusion Protein Ag18400 (353-422 aa encoded by BC104799)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FPSLRKMQE LLQTQDFSKF QALKPKLLDT VDDMLANDIA RLMVMVRQEE SLMPSQVVKG GAFDGTMNGP F (353-422 aa encoded by BC104799)
Target Information
EHD1 acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. EHD1 also plays a role in myoblast fusion and is recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Further, EHD1 belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The EHD1 protein is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for the EHD1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EH domain-containing protein 1; EH-domain containing 1; hPAST1; mPAST1; PAST homolog 1; Testilin
Gene Aliases: AA409636; CDABP0131; EHD1; H-PAST; HPAST1; PAST; PAST1; RME-1
UniProt ID: (Human) Q9H4M9, (Mouse) Q9WVK4
Entrez Gene ID: (Human) 10938, (Mouse) 13660
intracellular protein transport
endocytosis
blood coagulation
positive regulation of cholesterol storage
neuron projection development
endocytic recycling
low-density lipoprotein particle clearance
cilium assembly
cholesterol homeostasis
protein homooligomerization
protein localization to cilium
cell-cell adhesion
positive regulation of myoblast fusion
cellular response to nerve growth factor stimulus
positive regulation of endocytic recycling
endosomal transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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