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Fabgennix
EHD1 Polyclonal Antibody
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Product Details
EHD1-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken wtihin amino acid region 515-565 on human EH-domain containing protein 1.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
EHD1 acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. EHD1 also plays a role in myoblast fusion and is recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Further, EHD1 belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The EHD1 protein is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for the EHD1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EH domain-containing protein 1; hPAST1; mPAST1; PAST homolog 1; similar to Homo sapiens Hpast (HPAST) mRNA with GenBank Accession Number AF001434.1; Testilin; unnamed protein product
Gene Aliases: AA409636; CDABP0131; EHD1; H-PAST; HPAST1; PAST; PAST1; RGD1306960; RME-1
UniProt ID: (Human) Q9H4M9, (Mouse) Q9WVK4, (Rat) Q641Z6
Entrez Gene ID: (Human) 10938, (Mouse) 13660, (Rat) 293692
intracellular protein transport
endocytosis
positive regulation of cholesterol storage
positive regulation of neuron projection development
protein transport
endosomal transport
cell projection organization
neuron projection development
endocytic recycling
low-density lipoprotein particle clearance
cholesterol homeostasis
protein homooligomerization
cilium morphogenesis
protein localization to cilium
protein localization to plasma membrane
positive regulation of myoblast fusion
cellular response to nerve growth factor stimulus
positive regulation of endocytic recycling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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